A recent JAMA Cardiology paper examined the association between the use of quinolones commonly used for the treatment of respiratory infections (levofloxacin and moxifloxacin) and sudden cardiac death (SCD) over the next 5 days and compared this with the risk associated with the use of amoxicillin-based (amoxicillin or amoxicillin with clavulanic acid) treatment in 264 968…
SGLT2 inhibitors reduce the risk of clinically significant acute decline in kidney function in patients with CKD
It is fair to say that no other therapeutic agent has generated as much excitement in the kidney community in recent decades as SGLT2 inhibitors. Trial after trial has confirmed the substantive renoprotective and cardioprotective benefits on top of the standard of care including RAAS inhibitors. The initial studies however raised a few concerns, one…